Film coating involves the deposition of a thin layer of film-forming polymeric onto a product substrate. The process can be carried out using conventional panning equipment but nowadays more sophisticated equipment is used to achieve efficient drying, high degree of automation and coating time.
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What is meant by film coating?
A film coating is a thin polymer-based coat that is typically sprayed on to a solid pharmaceutical dosage form, such as a tablet, capsule, pellet or granule. Film coating can impact both its appearance and its pharmacokinetics making it an essential process in making the final drug product.
Why film coating is done?
Film coating is a common step in tablet manufacture that can be used to improve product appearance, organoleptic properties, or to facilitate swallowing. Functional film coats can also be used as a part of the product’s stabilisation strategy and to modify or delay drug release.
Which material is used for film coating?
Cellulosics, such as hydroxypropyl methyl cellulose (HPMC) , Hydroxypropyl cellulose (HPC), and ethyl cellulose (EC) Vinyls, such as polyvinyl alcohol. Acrylics, such as methacrylic acid / ethylacrylate copolymers (often used for enteric or delayed release coatings) Natural derivatives, such as shellac or alginates.
Which polymer is used for film coating?
The most widely used polymers in non-functional film coating are cellulose derivatives such as hypromellose. Plasticizers, used to improve the flexibility of the film formed and prevent it from cracking or breaking.
How is coating solution prepared?
preparation of the coating solution for the TFA- MOD method is shown in Fig. 1 in a 1:2:3 cation ratio in deionized water with a stoi- chiometric quantity of tri¯uoroacetic acid at room temperature. The resulting aqueous solution was re®ned for approximately 8 h under decompression to yield a glassy blue residue.
What are the various components of film coating solution?
The main components of film-coating formulations are a polymer, plasticizer, colorant, and solvent (or vehicle).
What are the two types of tablets?
There are different types of tablets: Chewable tablets dissolve and are absorbed rapidly in the stomach, offering a quick onset of action. They may come in different flavors. Orally disintegrating tablets dissolve on the tongue.
What is coating in pharma?
Tablet coating is a process by which an essentially dry, outer layer of coating material is applied to the surface of a dosage form in order to confer specific benefits over uncoated variety. Coatings may be applied to various oral dosage forms such as particles, powders, granules, crystals, pellets and tablets.
Why is sugar coating better than film coating?
Pharmaceutical tablets can be film coated in a single stage process that is rapid and results in minimal weight gain of at 2 – 3% compared with sugar coating which adds 60 to 80%. The film coat does not significantly affect the tablet’s disintegration process.
Why are tablets film coated?
Due to the increase in tablet size caused by sugar coating, drug manufacturers have largely changed to using ‘film coatings’. These are very thin layers of a safe ingredient placed around the tablet to again protect the tongue from the flavour of the contents and protect the contents from moisture and light.
What are the various types of film coated tablets?
Tablet coating is the outer covering of a tablet with a layer/substance.
- Sugar Coated Tablets.
- Film Coated Tablets.
- Gelatin Coated Tablets.
- Enteric Coated Tablets.
- Compression Coating Tablets.
- Other Types.
When was film coating invented?
1950s
The film coating process of today was introduced in the early 1950s as an improvement on the traditional sugar-coating process.
Do film coated tablets dissolve?
Dissolution problems with film-coated tablets occur when there is a statistically significant change in dissolution behavior after film coating (comparing film-coated tablets to uncoated ones).
What are the equipment used in coating process?
Standard coating pan
A significant improvement in the drying efficiency of the standard coating can easily be achieved by an immersion sword system, use of a baffled pan and diffuser (pellegrini pan system), and immersion tube systems.
How is coating of material calculated?
For example, if a coating were 45% solids by volume, its theoretical coverage would be 1604 X 0.45 or 722 square feet at 1 mil dry film thickness. If a specification called for a dry film thickness of 2 mils, the theoretical coverage would then be 722 square feet divided by 2 mils, or 361 square feet per gallon.
How do you calculate coating solution?
If solid content is 12%w/w and avg weight of tablet is 248mg and buildup is 3%. 3% weight gain means for each tablet the weight gain due to coating will be (248 x 3) / 100 = 7.44 mg.
What are the 4 types of medicines?
Types of medicines
- Liquid. The active part of the medicine is combined with a liquid to make it easier to take or better absorbed.
- Tablet. The active ingredient is combined with another substance and pressed into a round or oval solid shape.
- Capsules.
- Topical medicines.
- Suppositories.
- Drops.
- Inhalers.
- Injections.
What are the 3 categories of medicines?
These are:
- General Sales List.
- Pharmacy Medicines.
- Prescription Only Medicines.
- Controlled Drugs.
How many types of tablets are?
Hence, tablets can be broadly classified as compressed tablets and moulded tablets. Compressed tablets can be further classified as directly compressible tablets, chewable tablets and tablet triturates etc.
What is coating solution?
Solution coating is used to place a very thin layer of plastic onto a substrate; often fabric, paper, and electronic devices. A plastic is first dissolved in a suitable solvent, forming the solution with which to coat the substrate.